ASISCHEM P35096

ASISCHEM P35096 - Names and Identifiers

Name	N-Chloroacetyl-3-(trifluoromethyl)aniline
Synonyms	ASISCHEM P35096 ART-CHEM-BB B015650 TIMTEC-BB SBB003231 2-CHLORO-3'-(TRIFLUOROMETHYL)ACETANILIDE N-Chloroacetyl-3-(trifluoromethyl)aniline N-(CHLOROACETYL)-3-(TRIFLUOROMETHYL)ANILINE 2-CHLORO-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE N1-[3-(TRIFLUOROMETHYL)PHENYL]-2-CHLOROACETAMIDE
CAS	351-38-2
InChI	InChI=1/C9H7ClF3NO/c10-5-8(15)14-7-3-1-2-6(4-7)9(11,12)13/h1-4H,5H2,(H,14,15)

ASISCHEM P35096 - Physico-chemical Properties

Molecular Formula	C9H7ClF3NO
Molar Mass	237.61
Density	1.419±0.06 g/cm3(Predicted)
Melting Point	62,5-64°C
Boling Point	326.4±42.0 °C(Predicted)
Flash Point	151.2°C
Vapor Presure	0.000216mmHg at 25°C
pKa	12.35±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.513

ASISCHEM P35096 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S23 - Do not breathe vapour. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	IRRITANT

ASISCHEM P35096 - Introduction

N-Chloroacetyl-3-(trifluoromethyl)aniline is an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to light yellow crystalline or powdery solid.
-Solubility: Soluble in organic solvents such as ethanol, chloroform and acetone, insoluble in water.
-Molecular formula: C9H7ClF3NO.
-Molecular weight: 239.61.
-Melting point: 62-63 ℃.

Use:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is often used as an important intermediate in organic synthesis and has a wide range of applications.
-It can be used as an intermediate for certain drugs in the pharmaceutical field, such as anti-cancer drugs.
-It can also be used for the synthesis of pesticides.

Preparation Method:
The preparation of the N-Chloroacetyl-3-(trifluoromethyl)aniline can be completed by the following steps:
1. Dissolve aniline in dichloromethane.
2. Add N-chloroacetoimine and control the temperature below room temperature.
3. Reaction for several hours, then saturated aqueous hydrogen chloride solution is added.
4. Adjust the pH to basic with saturated sodium hydroxide solution and extract the product from the organic phase.
5. Finally, the target product is obtained by crystallization or purification process.

Safety Information:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is an organic substance with certain toxicity.
-During operation, protective gloves, protective glasses and protective masks must be worn to avoid direct contact and inhalation.
-When storing and handling, keep away from ignition and oxidizing agents.

Last Update：2024-04-09 02:00:45